New Cytotoxic Sesquiterpenes from the Gorgonian Isis hippuris

Jyh-Horng Sheu,* Kuang-Chih Hung, Guey-Horng Wang, and Chang-Yih Duh
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, Republic of China
J. Nat. Prod., 2000, 63 (12), pp 1603–1607
DOI: 10.1021/np000271n
Publication Date (Web): October 24, 2000
Copyright © 2000 American Chemical Society and American Society of Pharmacognosy
*

 To whom correspondence should be addressed. Tel.:  886-7-5252000, ext. 5030. Fax:  886-7-5255020. E-mail:  sheu@mail.nsysu.edu.tw.

Abstract

Five new suberosane sesquiterpenes, suberosenol A (1), suberosenol B (2), suberosanone (3), suberosenol A acetate (4), and suberosenol B acetate (5), along with the known sesquiterpene subergorgic acid (6), have been isolated from the gorgonian Isis hippuris. The structures of these metabolites were established by spectroscopic and chemical methods. Metabolites 1 and 3−5 were found to exhibit potent cytotoxicity toward P-388, A549, and HT-29 cancer cell lines.

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History

  • Published In Issue December 27, 2000
  • Received May 31, 2000

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