Pachyclavulariaenones D−G, New Diterpenoids from the Soft Coral Pachyclavularia violacea

Guey-Horng Wang,† Jyh-Horng Sheu,*† Chang-Yih Duh,† and Michael Y. Chiang‡
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan, and Department of Chemistry, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan, Republic of China
J. Nat. Prod., 2002, 65 (10), pp 1475–1478
DOI: 10.1021/np020095d
Publication Date (Web): September 4, 2002
Copyright © 2002 American Chemical Society and American Society of Pharmacognosy
†

 Department of Marine Resources.

,
*

 To whom correspondence should be addressed. Tel:  886-7-5252000, ext. 5030. Fax:  886-7-5255020. E-mail:  sheu@mail.nsysu.edu.tw.

,
‡

 Department of Chemistry.

Abstract

Four new diterpenoids, pachyclavulariaenones D−G (1−4), have been isolated from the soft coral Pachyclavularia violacea. The structures and relative stereochemistry of metabolites 1−4 were established on the basis of extensive NMR studies and chemical methods. The structure, including the relative configuration of pachyclavulariaenone F (3), was further confirmed by a single-crystal X-ray analysis. Pachyclavulariaenone G (4) has been shown to exhibit significant cytotoxicity toward P-388 and HT-29 cancer cells.

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History

  • Published In Issue October 25, 2002
  • Received March 20, 2002

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