Hippuristerones E−I, New Polyoxygenated Steroids from the Gorgonian Coral Isis hippuris

Jyh-Horng Sheu,*† Long-Fei Huang,† Shin-Pin Chen,† Yi-Lea Yang,† Ping-Jyun Sung,† Guey-Horng Wang,†‡ Jui-Hsin Su,† Chih-Hua Chao,† Wan-Ping Hu,§ and Jeh-Jeng Wang§
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China, Center for General Education, Hsing-Kuo University, Tainan 709, Taiwan, Republic of China, and School of Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China
J. Nat. Prod., 2003, 66 (7), pp 917–921
DOI: 10.1021/np020602r
Publication Date (Web): May 15, 2003
Copyright © 2003 American Chemical Society and American Society of Pharmacognosy
*

 To whom correspondence should be addressed. Tel:  886-7-5252000, ext. 5030. Fax:  886-7-5255020. E-mail:  sheu@mail.nsysu.edu.tw.

,
†

 National Sun Yat-Sen University.

,
‡

 Hsing-Kuo University.

,
§

 Kaohsiung Medical University.

Abstract

Five novel (22R,23S,24S)-steroids, hippuristerones E−I (1−5), have been isolated from the gorgonian coral Isis hippuris. The structures of steroids 1−5 were deduced by extensive 1D and 2D NMR studies (1H, 13C, 1H−1H COSY, HMQC, HMBC, and NOESY experiments). The structure of 1 was further supported by molecular mechanics calculations.

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History

  • Published In Issue July 25, 2003
  • Received December 31, 2002

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