Polyoxygenated Steroids from the Gorgonian Isis hippuris

Chih-Hua Chao,† Long-Fei Huang,† Yi-Lea Yang,† Jui-Hsin Su,† Guey-Horng Wang,‡ Michael Y. Chiang,§ Yang-Chang Wu, Chang-Feng Dai, and Jyh-Horng Sheu*†
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China, Center of General Education, Hsing-Kuo University, Tainan 709, Taiwan, Republic of China, Department of Chemistry, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China, Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China, and Institute of Oceanography, National Taiwan University, Taipei 106, Taiwan, Republic of China.
J. Nat. Prod., 2005, 68 (6), pp 880–885
DOI: 10.1021/np050033y
Publication Date (Web): May 25, 2005
Copyright © 2005 American Chemical Society and American Society of Pharmacognosy
†

 Department of Marine Resources, National Sun Yat-Sen University.

,
‡

 Hsing-Kuo University.

,
§

 Department of Chemistry, National Sun Yat-Sen University.

,

 Kaohsiung Medical University.

,

 National Taiwan University.

,
*

 To whom correspondence should be addressed. Tel:  886-7-5252000 ext. 5030. Fax:  886-7-5255020. E-mail:  sheu@mail.nsysu.edu.tw, sheu@ mail.nsysu.edu.tw.

Abstract

Abstract Image

Eleven new hippuristanols (1−4, 7−9, and 11−14), along with eight known metabolites (5, 6, 10, and 15−19), have been isolated from the gorgonian coral Isis hippuris. Single-crystal X-ray diffraction analyses supported the structure elucidation of known steroids 5 and 10. The absolute structures of hippuristanols were established by application of modified Mosher's method on 19. Compounds 14−19 have been found to exhibit significant cytotoxicity against several cancer cell lines.

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History

  • Published In Issue June 24, 2005
  • Received January 28, 2005

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