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Eunicellin-Based Diterpenoids, Australins A−D, Isolated from the Soft Coral Cladiella australis

Atallah F. Ahmed,^†^‡ Ming-Hsuan Wu,^† Guey-Horng Wang,^§ Yang-Chang Wu, and Jyh-Horng Sheu*^†

Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China, Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt, Center of General Education, Hsing-Kuo University, Tainan 709, Taiwan, Republic of China, and Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China

J. Nat. Prod., 2005, 68 (7), pp 1051–1055

DOI: 10.1021/np0500732

Publication Date (Web): July 7, 2005

†

National Sun Yat-Sen University.

‡

Mansoura University.

Hsing-Kuo University.

Kaohsiung Medical University.

To whom correspondence should be addressed. Tel: 886-7-5252000, ext. 5030. Fax: 886-7-5255020. E-mail: sheu@mail.nsysu.edu.tw.

Abstract

The EtOAc extract of a Taiwanese soft coral, Caldiella australis, yielded four new eunicellin-based diterpenoids, australins A−D (1−4). The chemical structures of these metabolites were determined on the basis of extensive spectroscopic (including 1D and 2D NMR) analyses and by comparison of their NMR spectral data with those of related metabolites. Metabolite 2 was found to possess a moderate cytotoxic activity against selected breast and liver cancer cell lines.

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