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Article

Using Jasplakinolide to Turn on Pathways that Enable the Isolation of New Chaetoglobosins from Phomospis asparagi

Supporting Info

Omar E. Christian,^† Jennifer Compton,^† Keisha R. Christian,^† Susan L. Mooberry,^‡ Fredrick A. Valeriote,^§ and Phillip Crews*^†

Department of Chemistry and Biochemistry and Institute for Marine Sciences, University of California, Santa Cruz, California 95064, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, and Division of Hematology and Oncology, Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan 48202

J. Nat. Prod., 2005, 68 (11), pp 1592–1597

DOI: 10.1021/np050293f

Publication Date (Web): October 29, 2005

†

University of California Santa Cruz.

‡

Southwest Foundation for Biomedical Research.

Henry Ford Health System.

To whom correspondence should be addressed. Tel: 831 459-2603. Fax: 831 459-2935. E-mail: phil@chemistry.ucsc.edu.

Abstract

The isolation and structure elucidation of three new secondary metabolites, chaetoglobosin-510 (1), -540 (2), and -542 (3), are described. These compounds were produced by cultures of the marine-derived fungus Phomopsis asparagi, challenged with the known F-actin inhibitor jasplakinolide. Chaetoglobosin-542 (3) displayed antimicrofilament activity and was cytotoxic toward murine colon and leukemia cancer cell lines.

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Published In Issue November 28, 2005
Received August 12, 2005

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Article

Using Jasplakinolide to Turn on Pathways that Enable the Isolation of New Chaetoglobosins from Phomospis asparagi

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

Nodulisporic Acids D−F: Structure, Biological Activities, and Biogenetic Relationships

Engineering of the Spinosyn PKS: Directing Starter Unit Incorporation

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