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Antifungal Flavonoids from Hildegardia barteri

Tamara L. Meragelman,^† Kenneth D. Tucker,^‡^§ Thomas G. McCloud,^‡ John H. Cardellina II,*^† and Robert H. Shoemaker^†

Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, and SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, Maryland 21702-1201

J. Nat. Prod., 2005, 68 (12), pp 1790–1792

DOI: 10.1021/np0503000

Publication Date (Web): December 2, 2005

†

Screening Technologies Branch.

‡

SAIC-Frederick, Inc.

Current address: NBACC, 7435 New Technology Way, Frederick, MD 21703.

To whom correspondence should be addressed. Tel: 301-846-1121. Fax: 301-846-6775. E-mail: jcardellina@ncifcrf.gov.

Abstract

A new isoflavan, (3R)-6,2‘-dihydroxy-7-methoxy-4‘,5‘-methylenedioxyisoflavan, hildegardiol (1), and two known flavonoids, 2-hydroxymaackiain (2) and farrerol (3), were isolated from the antifungal root extract of Hildegardia barteri. The pterocarpan 2 was largely responsible for the observed antifungal activity.

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Published In Issue December 26, 2005
Received August 16, 2005

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Antifungal Flavonoids from Hildegardia barteri

Abstract

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Related Content

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Prenylated Flavonoids from the Root Bark of Berchemia discolor, a Tanzanian Medicinal Plant

The Role of Natural Product Chemistry in Drug Discovery

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