5-Alkylresorcinols from Merulius incarnatus

Wentao Jin and Jordan K. Zjawiony*
Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848
J. Nat. Prod., 2006, 69 (4), pp 704–706
DOI: 10.1021/np050520d
Publication Date (Web): March 17, 2006
Copyright © 2006 American Chemical Society and American Society of Pharmacognosy
*

 To whom correspondence should be addressed. E-mail:  jordan@olemiss.edu. Tel:  662-915-7290. Fax:  662-915-6975.

Abstract

Abstract Image

Two new, 5-heptadeca-8‘Z,11‘Z,16-trienylresorcinol (1) and 5-heptadeca-9‘E,11‘Z,16-trienylresorcinol (2), and six known 5-alkylresorcinols (3−8) were isolated from the mushroom Merulius incarnatus. Compound 2 is the first 5-alkylresorcinol derivative that contains a trans−cis conjugated double bond system. Compounds 1, 2, 5, 6, 7, and 8 were found to inhibit methacillin-resistant Staphylococcus aureus (MRSA) with IC50 values of 2.5, 15, 9.5, 8.0, 5.0, and 6.5 μg/mL, respectively. Compound 1 was also active against leishmania, with an IC50 value of 3.6 μg/mL, and showed no cytotoxicity in our Vero cell test up to a concentration of 25 μg/mL. The structures of these isolates were determined by spectroscopic data including 1D and 2D NMR.

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History

  • Published In Issue April 28, 2006
  • Received December 8, 2005

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