19-Nor- and 18,20-Epoxy-cardenolides from the Leaves of Calotropis gigantea

Thitima Lhinhatrakool and Somyote Sutthivaiyakit*
Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkapi, Bangkok 10240, Thailand
J. Nat. Prod., 2006, 69 (8), pp 1249–1251
DOI: 10.1021/np060249f
Publication Date (Web): August 8, 2006
Copyright © 2006 American Chemical Society and American Society of Pharmacognosy
*

 Corresponding author. Tel:  (662) 319-0931. Fax:  (662) 319-1900. E-mail:  somyote_s@yahoo.com.

Abstract

Abstract Image

Two new cardenolides (1 and 2) along with 12 known compounds were isolated from the dichloromethane extract of the leaves of Calotropis gigantea. The structural elucidation was accomplished by spectroscopic methods. Some of the isolates were evaluated for cytotoxic activity against KB, BC, and NCI-H187 cancer cell lines, and all cardenolides tested were found to possess strong inhibitory effects. The presence of a deoxysugar at C-3, a formyl group at C-10, and an α,β-unsaturated γ-lactone was crucial for cytotoxic activity.

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History

  • Published In Issue August 25, 2006
  • Received June 3, 2006

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