Bioactive Lignans from Peperomia heyneana

Guo-Liang Zhang,†‡ Na Li,*† Yun-Hua Wang,§ Yong-Tang Zheng,§ Zhen Zhang,† and Ming-Wei Wang*†
The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and the Graduate School, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Zhangjiang Hi-Tech Park, Shanghai 201203, Peoples Republic of China, and Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, Peoples Republic of China
J. Nat. Prod., 2007, 70 (4), pp 662–664
DOI: 10.1021/np0605236
Publication Date (Web): February 10, 2007
Copyright © 2007 American Chemical Society and American Society of Pharmacognosy
†

 The National Center for Drug Screening.

,
‡

 Graduate School of the Chinese Academy of Sciences.

,
*

 To whom correspondence should be addressed. Tel:  86-21-50801313. Fax:  86-21-50800721. E-mail:  nli@mail.shcnc.ac.cn (chemistry) and mwwang@mail.shcnc.ac.cn (pharmacology).

,
§

 Kunming Institute of Zoology.

Abstract

Abstract Image

Four new compounds, including three secolignans (1−3) and one tetrahydrofuran lignan (4), were isolated from the petroleum ether and EtOAc fractions of Peperomia heyneana. These compounds were accompanied by eight known secolignans, one known tetrahydrofuran lignan, one known cyclohexenone, and one known amide. The structures were elucidated mainly by 1D and 2D NMR and MS experiments, and the relative configurations by NOE techniques. Five compounds were evaluated for their inhibitory activities against HIV-1 in infected C8166 cells.

View: Full Text HTML | Hi-Res PDF

Tools

History

  • Published In Issue April 27, 2007
  • Received October 23, 2006

Recommend & Share

Related Content

Other ACS content by these authors: