Additional Scalarane Sesterterpenes from the Sponge Phyllospongia papyracea

Hou-Jin Li,†‡ Taro Amagata,† Karen Tenney,† and Phillip Crews*†
Department of Chemistry and Biochemistry and Institute for Marine Sciences, University of California Santa Cruz, Santa Cruz, California 95064, and School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, People's Republic of China
J. Nat. Prod., 2007, 70 (5), pp 802–807
DOI: 10.1021/np070020f
Publication Date (Web): April 25, 2007
Copyright © 2007 American Chemical Society and American Society of Pharmacognosy
†

 University of California Santa Cruz.

,
‡

 Sun Yat-sen University.

,
*

 To whom correspondence should be addressed. Tel:  (831) 459-2603. Fax:  (831) 459-2935. E-mail:  phil@chemistry.ucsc.edu.

Abstract

Abstract Image

A chemical investigation of the marine sponge Phyllospongia papyracea, collected in Papua New Guinea, initiated by the screening result of a β-catenin/Tcf4 disruption assay afforded six new bishomoscalarane sesterterpenes containing two rare scalaranes with a cyclobutane ring in the molecule, together with one known scalarane sesterterpene. The structures of the new compounds were elucidated by 1D and 2D spectroscopic techniques. The compounds isolated in this study did not show activity against the β-catenin and Tcf4 complex.

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History

  • Published In Issue May 25, 2007
  • Received January 12, 2007

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