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Sesquiterpenoids and Artificial 19-Oxygenated Steroids from the Formosan Soft Coral Nephthea erecta

Shi-Yie Cheng^†, Chang-Feng Dai^‡ and Chang-Yih Duh*^†^§

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Republic of China, Institute of Oceanography, National Taiwan University, Taipei, Taiwan, Republic of China, and Center of Asia-Pacific Marine Researches, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China

J. Nat. Prod., 2007, 70 (9), pp 1449–1453

DOI: 10.1021/np070189t

Publication Date (Web): September 11, 2007

†

National Sun Yat-sen University.

‡

National Taiwan University.

* To whom correspondence should be addressed. Tel: 886-7-5252000 , ext. 5036. Fax: 886-7-5255020. E-mail: yihduh@nsysu.edu.tw.

Center of Asia-Pacific Marine Researches.

Abstract

Chemical investigations on the acetone and MeOH solubles of the soft coral Nephthea erecta have afforded five new sesquiterpenoids (1–5), one known sesquiterpene, kelsoene (6), and two known 19-oxygenated steroids (10 and 11). In addition, three unexpected artificial 19-oxygenated steroids (7–9) were obtained by letting 10 and 11 stand in CDCl₃ for prolonged periods of time. The structures of 1–9 were elucidated by extensive spectroscopic analyses, and their cytotoxicity against selected cancer cells was measured in vitro.

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Published In Issue September 28, 2007
Article ASAPSeptember 11, 2007
Received: April 25, 2007

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Article

Sesquiterpenoids and Artificial 19-Oxygenated Steroids from the Formosan Soft Coral Nephthea erecta

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