Kadsuralignans H−K from Kadsura coccinea and Their Nitric Oxide Production Inhibitory Effects

Heran Li, Liyan Wang, Zhigang Yang and Susumu Kitanaka*
College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan
J. Nat. Prod., 2007, 70 (12), pp 1999–2002
DOI: 10.1021/np070269x
Publication Date (Web): November 21, 2007
Copyright © 2007 The American Chemical Society and American Society of Pharmacognosy and American Society of Pharmacognosy
* Corresponding author. Phone: 81-47-465-5356 . Fax: 81-47-465-5440. E-mail: kitanaka@pha.nihon-u.ac.jp.

Abstract

Abstract Image

One new arylnaphthalene lignan named kadsuralignan H (1) and three new dibenzocyclooctadiene lignans, named kadsuralignans I (2), J (3), and K (4), respectively, were isolated from an EtOAc fraction of the 80% acetone extract of Kadsura coccinea. The structures were elucidated on the basis of spectroscopic evidence. Compound 1 is the second arylnaphthalene lignan isolated from the Kadsura genus. Compounds 1 and 3 showed inhibitory activity on nitric oxide (NO) production by the murine macrophage-like cell RAW264.7, which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-γ (INF-γ).

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History

  • Published In Issue December 28, 2007
  • Article ASAPNovember 21, 2007
  • Received: June 07, 2007

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