Phloroglucinols with Antioxidant Activity and Xanthonolignoids from the Heartwood of Hypericum geminiflorum

Chien-Chang Wu†, Ming-Hong Yen*‡, Shyh-Chyun Yang† and Chun-Nan Lin*†‡
School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China, and Institute of Life Science, National Taitung University, Taitung 950, Taiwan, Republic of China
J. Nat. Prod., 2008, 71 (6), pp 1027–1031
DOI: 10.1021/np8001145
Publication Date (Web): May 31, 2008
Copyright © 2008 The American Chemical Society and American Society of Pharmacognosy
†

Kaohsiung Medical University.

,
* To whom correspondence should be addressed. Tel: +886 7 3121101, ext. 2163 . Fax: +886 7 5562365. E-mail: lincna@cc.kmu.edu.tw (C.-N.L.); yen@kmu.edu.tw (M.-H.Y.).
,
‡

National Taitung University.

Abstract

Abstract Image

A new phloroglucinol, hyperielliptone HA (1/1a), a new spirophloroglucinol possessing an unprecedented skeleton, hyperielliptone HB (2/2a), and two new xanthonolignoids, hyperielliptones HC (3) and HD (4), were isolated from the heartwood of Hypericum geminiflorum. Compounds 1/1a and 2/2a were obtained as tautomeric pairs. The structures and relative configurations of these compounds were elucidated by spectroscopic methods. In biological testing, compound 2/2a revealed significant inhibition of oxidative DNA damage and an inhibitory effect on xanthine oxidase.

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History

  • Published In Issue June 27, 2008
  • Article ASAPMay 31, 2008
  • Received: February 20, 2008

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