Next Article Table of Contents

Article

Cytotoxic Acacic Acid Glycosides from the Roots of Albizia coriaria

Supporting Info

Olivier Placide Not

^†^‡, Anne-Claire Mitaine-Offer^†, Tomofumi Miyamoto^§, Thomas Paululat, Jean-Fran

ois Mirjolet, Olivier Duchamp, Dieudonn

Emmanuel Pegnyemb^‡ and Marie-Aleth Lacaille-Dubois*^†

Laboratoire de Pharmacognosie, UMIB, EA 3660, Facult

de Pharmacie, Universit

de Bourgogne, 7 Boulevard Jeanne D’Arc, BP 87900, 21079 Dijon Cedex, France, Laboratoire de Pharmacochimie, D

partement de Chimie Organique, Facult

des Sciences, Universit

de Yaound

, BP 812, Yaound

, Cameroon, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan, and Universit

t Siegen FB8, OC-II (AK Ihmels), Adolf-Reichwein-Strasse 2, D-57068 Siegen, Germany, and Oncodesign, 20 Rue Jean Mazen, BP27627, 21076 Dijon Cedex, France

J. Nat. Prod., 2009, 72 (10), pp 1725–1730

DOI: 10.1021/np900126r

Publication Date (Web): September 24, 2009

* Corresponding author. Tel.: +33 3 80 39 32 29. Fax: +33 3 80 39 33 00. E-mail: m-a.lacaille-dubois@u-bourgogne.fr., †

Universit de Bourgogne.

, ‡

Universit de Yaound.

, §

Kyushu University.

Universitt Siegen.

Oncodesign.

Abstract

Two new oleanane-type saponins, coriariosides A (1) and B (2), along with a known saponin, gummiferaoside C (3), were isolated from the roots of Albizia coriaria. Their structures were established by extensive analysis of 1D and 2D NMR experiments (COSY, ROESY, TOCSY, HSQC, and HMBC) and mass spectrometry. Compounds 1 and 3 when tested for cytotoxicity against two colorectal human cancer cells showed activity against the HCT 116 (IC₅₀ 4.2 μM for 1 and 2.7 μM for 3) and HT-29 (IC₅₀ 6.7 μM for 1 and 7.9 μM for 3) cell lines.

View: Full Text HTML | Hi-Res PDF | PDF w/ Links

Tools

SciFinder Links

Explore by:

Author of this Article Any Author Research Topic

History

Published In Issue October 23, 2009
Article ASAPSeptember 24, 2009
Received: February 25, 2009

Recommend & Share

Related Content

Triterpenoid Saponins from Rubus ellipticus var. obcordatusJournal of Natural Products
- Triterpenoid Saponins from Rubus ellipticus var. obcordatus
  Wei Li, Hongwei Fu, Hong Bai, Tatsunori Sasaki, Hiroyoshi Kato and Kazuo Koike
  Journal of Natural Products 2009 72 (10), pp 1755–1760
  Abstract: Ten new triterpenoid saponins (1−10), named rubusides A−J, and 21 known saponins (11−31) were isolated from the roots of Rubus ellipticus var. obcordatus. The structures of 1−10 were established on the basis of spectroscopic analyses, mainly NMR and MS, ...
  Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF
Anti-Tumor-Promoting Effects of 25-Methoxyporicoic Acid A and Other Triterpene Acids from Poria cocosJournal of Natural Products
- Anti-Tumor-Promoting Effects of 25-Methoxyporicoic Acid A and Other Triterpene Acids from Poria cocos
  Toshihiro Akihisa, Emiko Uchiyama, Takashi Kikuchi, Harukuni Tokuda, Takashi Suzuki and Yumiko Kimura
  Journal of Natural Products 2009 72 (10), pp 1786–1792
  Abstract: Nine new (1, 3, 5, 8, 12, 13, 15, 17, and 18) and nine known (2, 4, 6, 7, 9−11, 14, and 16) lanostane-type triterpene acids and a known diterpene acid (19) were isolated from the epidermis of the sclerotia of Poria cocos. The structures of the new ...
  Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF
Cytotoxic Compounds from the Stems of Cinnamomum tenuifoliumJournal of Natural Products
- Cytotoxic Compounds from the Stems of Cinnamomum tenuifolium
  Rong-Jyh Lin, Ming-Jen Cheng, Jin-Cherng Huang, Wen-Li Lo, Yu-Ting Yeh, Chung-Min Yen, Chin-Mei Lu and Chung-Yi Chen
  Journal of Natural Products 2009 72 (10), pp 1816–1824
  Abstract: Three new butanolides, tenuifolide A (1), isotenuifolide A (2), and tenuifolide B (3), a new secobutanolide, secotenuifolide A (4), and one new sesquiterpenoid, tenuifolin (5), along with 16 known compounds were isolated from the stems of Cinnamomum ...
  Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF

Article

Cytotoxic Acacic Acid Glycosides from the Roots of Albizia coriaria

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Triterpenoid Saponins from Rubus ellipticus var. obcordatus

Anti-Tumor-Promoting Effects of 25-Methoxyporicoic Acid A and Other Triterpene Acids from Poria cocos

Cytotoxic Compounds from the Stems of Cinnamomum tenuifolium

Other ACS content by these authors:

JOURNALS

BOOKS

MAGAZINE

COMMUNITIES

DIRECTORIES & DATABASES