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Curcumin Inhibits ACTH- and Angiotensin II-Stimulated Cortisol Secretion and Ca_v3.2 Current

Judith A. Enyeart, Haiyan Liu and John J. Enyeart*

Department of Neuroscience, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210-1239

J. Nat. Prod., 2009, 72 (8), pp 1533–1537

DOI: 10.1021/np900227x

Publication Date (Web): August 4, 2009

* Corresponding author. Phone: (614) 292-3511. Fax: (614) 688-8742. E-mail: enyeart.1@osu.edu.

Abstract

Adrenocorticotropic hormone and angiotensin II stimulate cortisol secretion from bovine adrenal zona fasciculata cells by the activation of adenylate cyclase and phospholipase C-coupled receptors. Curcumin (1− 20 μM), a compound found in the spice turmeric, inhibited cortisol secretion stimulated by ACTH, AngII, and 8CPT-cAMP. Curcumin also suppressed ACTH-stimulated increases in mRNAs coding for steroid acute regulatory protein and CYP11a1 steroid hydroxylase. In whole cell patch clamp recordings from AZF cells, curcumin at slightly higher concentrations also inhibited Ca_v3.2 current. These results identify curcumin as an effective inhibitor of ACTH- and AngII-stimulated cortisol secretion. The inhibition of Ca_v3.2 current by curcumin may contribute to its suppression of secretion.

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History

Published In Issue August 28, 2009
Article ASAPAugust 04, 2009
Received: April 13, 2009

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Curcumin Inhibits ACTH- and Angiotensin II-Stimulated Cortisol Secretion and Ca_v3.2 Current