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Article

Triterpenoid Saponins from Rubus ellipticus var. obcordatus

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Wei Li*^†, Hongwei Fu^†^‡, Hong Bai^§, Tatsunori Sasaki^†, Hiroyoshi Kato^† and Kazuo Koike^†

Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan, Zhejiang Provincial Key Laboratory for Chinese Medicine Screening, Exploitation & Medicinal Effectiveness Appraise for Cardio-cerebral Vascular & Nervous System, The Key Laboratory of Biomedical Engineering Ministry of Education, China, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, People’s Republic of China, and Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, People’s Republic of China

J. Nat. Prod., 2009, 72 (10), pp 1755–1760

DOI: 10.1021/np900237a

Publication Date (Web): October 1, 2009

* To whom correspondence should be addressed. Tel: +81-47-4721161. Fax: +81-47-4721404. E-mail: liwei@phar.toho-u.ac.jp., †

Toho University.

, ‡

Zhejiang University.

, §

Shandong Academy of Medical Sciences.

Abstract

Ten new triterpenoid saponins (1−10), named rubusides A−J, and 21 known saponins (11−31) were isolated from the roots of Rubus ellipticus var. obcordatus. The structures of 1−10 were established on the basis of spectroscopic analyses, mainly NMR and MS, and chemical degradations. The compounds demonstrated inhibitory activities against α-glucosidase with IC₅₀ values in the range 0.65−3.09 mM.

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Published In Issue October 23, 2009
Article ASAPOctober 01, 2009
Received: April 30, 2009

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Article

Triterpenoid Saponins from Rubus ellipticus var. obcordatus

Abstract

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