Cytotoxic neo-Clerodane Diterpenoid Alkaloids from Scutellaria barbata

Sheng-Jun Dai*†, Wei-Bing Peng‡, De-Wu Zhang†, Li Shen‡, Wen-Yan Wang† and Yan Ren†
School of Pharmaceutical Science, Yantai University, Yantai 264005, People’s Republic of China, and Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drug and Food, Ocean University of China, Qingdao 266003, People’s Republic of China
J. Nat. Prod., 2009, 72 (10), pp 1793–1797
DOI: 10.1021/np900362z
Publication Date (Web): September 28, 2009
Copyright © 2009 The American Chemical Society and American Society of Pharmacognosy
* To whom correspondence should be addressed. E-mail: daishengjun_9@hotmail.com. Tel: +86-535-6706025. Fax: +86-535-6706036., †

Yantai University.

, ‡

Ocean University of China.

Abstract

Abstract Image

Six new neo-clerodane diterpenoid alkaloids, named scutehenanines A−D (1, 4, 5, 6), 6-O-acetylscutehenanine A (2), and 6-O-(2-carbonyl-3-methylbutanoyl)scutehenanine A (3), were isolated from the whole plant of Scutellaria barbata. Their structures were established on the basis of detailed physical data analyses. In vitro, the six new isolated compounds showed cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells) and gave IC50 values in the range 2.8−6.4 μM.

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History

  • Published In Issue October 23, 2009
  • Article ASAPSeptember 28, 2009
  • Received: June 19, 2009

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