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Xanalteric Acids I and II and Related Phenolic Compounds from an Endophytic Alternaria sp. Isolated from the Mangrove Plant Sonneratia alba

Supporting Info

Julia Kjer^†, Victor Wray^‡, RuAngelie Edrada-Ebel^§, Rainer Ebel, Alexander Pretsch, Wenhan Lin* and Peter Proksch*^†

Institut f

r Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universit

t D

sseldorf, Universit

tsstrasse 1, Geb. 26.23, 40225 D

sseldorf, Germany, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany, Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, The John Arbuthnott Building, 27 Taylor Street, Glasgow G4 0NR, U. K., Department of Chemistry, University of Aberdeen, Meston Building, Meston Walk, AB24 3UE, Aberdeen, U.K., SeaLife Pharma GmbH, Technopark 1, 3430 Tulln, Austria, and National Research Laboratories of Natural and Biomimetic Drugs, Peking University, Health Science Center, 100083 Beijing, People’s Republic of China

J. Nat. Prod., 2009, 72 (11), pp 2053–2057

DOI: 10.1021/np900417g

Publication Date (Web): October 16, 2009

* Corresponding authors. (P.P.) Tel: ++49-211-81-14163. Fax: ++49-211-81-11923. E-mail: proksch@uni-duesseldorf.de. (W.L.) Tel: ++86-10-82806188. Fax: ++86-10-82802724. E-mail: whlin@bjmu.edu.cn., †

Heinrich-Heine Universitt, Dsseldorf.

, ‡

Helmholtz Centre for Infection Research, Braunschweig.

, §

University of Strathclyde, Glasgow.

University of Aberdeen.

SeaLife Pharma, Tulln.

Peking University.

Abstract

Two new 10-oxo-10H-phenaleno[1,2,3-de]chromene-2-carboxylic acids, xanalteric acids I (1) and II (2), and 11 known secondary metabolites were obtained from extracts of the endophytic fungus Alternaria sp., isolated from the mangrove plant Sonneratia alba collected in China. The metabolites were confirmed to be of fungal origin, and the structures of the new natural products were unambiguously elucidated on the basis of extensive one- and two-dimensional NMR spectroscopic studies and mass spectrometric analysis. The two new compounds 1 and 2 exhibited weak antibiotic activity against multidrug-resistant Staphylococcus aureus. Altenusin (3) displayed broad antimicrobial activity against several additional multidrug-resistant bacterial and fungal strains.

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