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Article

Bioactive Constituents of the Stem Bark of Mitrephora glabra

Supporting Info

Chen Li^†^‡, Dongho Lee^†^§, Tyler N. Graf^†^¶, Sharnelle S. Phifer^†, Yuka Nakanishi^†, Soedarsono Riswan, Fransisca M. Setyowati, Achmad M. Saribi, Djaja D. Soejarto, Norman R. Farnsworth, Joseph O. Falkinham, III^°, David J. Kroll^†^#, A. Douglas Kinghorn^±, Mansukh C. Wani^† and Nicholas H. Oberlies*^†^¶

Natural Products Laboratory, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, Herbarium Borgoriense, Research and Development Center for Biology, Indonesian Institute of Science, 16122 Bogor, Indonesia, Regional Planning and Development Board (BAPPEDA), Kapuas Regency, Central Kalimantan, Indonesia, Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0406, and College of Pharmacy, The Ohio State University, Columbus, Ohio 43210

J. Nat. Prod., 2009, 72 (11), pp 1949–1953

DOI: 10.1021/np900572g

Publication Date (Web): October 29, 2009

* To whom correspondence should be addressed. Tel: (336) 334-5474. Fax: (336) 334-5402. E-mail: Nicholas_Oberlies@UNCG.edu.., †

Research Triangle Institute.

, ¶

Current address: Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, 435 Sullivan Sciences Building, Greensboro, NC 27402.

, ‡

Current address: Cubist Pharmaceuticals, 65 Hayden Ave., Lexington, MA 02421.

, §

Current address: School of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Korea.

Indonesian Institute of Science.

BAPPEDA.

University of Illinois at Chicago.

, °

Virginia Polytechnic Institute and State University.

, #

Current address: Department of Pharmaceutical Sciences, BRITE, North Carolina Central University, Durham, NC 27707.

, ±

The Ohio State University.

Abstract

Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three ent-kaurenoids (1−3), five polyacetylenic acids/esters (4−8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1−3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms.