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Article

Study on Cytotoxic Oxygenated Desmosterols Isolated from the Red Alga Galaxaura marginata

Jyh-Horng Sheu,* Shiang-Yuh Huang, Guey-Horng Wang, and Chang-Yih Duh

Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, Republic of China

J. Nat. Prod., 1997, 60 (9), pp 900–903

DOI: 10.1021/np9701844

Publication Date (Web): September 22, 1997

Author to whom correspondence should be addressed. Phone: 886-7-5252000 (ext 5030). FAX: 886-7-5255020.

Abstract

Four novel oxygenated desmosterols, 24ξ-hydroperoxy-6β-hydroxycholesta-4,25-dien-3-one (1), 25-hydroperoxy-6β-hydroxycholesta-4,23(E)-dien-3-one (2), 24ξ-hydroperoxycholesta-4,25-diene-3,6-dione (3), and 25-hydroperoxycholesta-4,23(E)-diene-3,6-dione (4) were isolated from the marine red alga Galaxaura marginata. Steroids 1−4 and three synthetic oxygenated desmosterols 5−7 were shown to exhibit significant cytotoxicity against several cancer cell lines.