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Article

New Cytotoxic Oxygenated Fucosterols from the Brown Alga Turbinaria conoides

Jyh-Horng Sheu,* Guey-Horng Wang, Ping-Jyun Sung, and Chang-Yih Duh

Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, Republic of China

J. Nat. Prod., 1999, 62 (2), pp 224–227

DOI: 10.1021/np980233s

Publication Date (Web): December 5, 1998

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Abstract

Fucosterol (1), 24ξ-hydroperoxy-24-vinylcholesterol (2), 29-hydroperoxystigmasta-5,24(28)-dien-3β-ol (3), 24-ethylcholesta-4,24(28)-dien-3-one (4), 24ξ-hydroperoxy-24-ethylcholesta-4,28(29)-dien-3-one (5), 24-ethylcholesta-4,24(28)-dien-3,6-dione (6), 24ξ-hydroperoxy-24-ethylcholesta-4,28(29)-dien-3,6-dione (7), 6β-hydroxy-24-ethylcholesta-4,24(28)-dien-3-one (8), and 24ξ-hydroperoxy-6β-hydroxy-24-ethylcholesta-4,28(29)-dien-3-one (9) were isolated from the marine brown alga Turbinaria conoides. The structures of these compounds were established by spectral analysis. Isolated for the first time from a natural source, the oxygenated fucosterols 4−9 exhibit cytotoxicity against various cancer cell lines.