Excavatolides F−M, New Briarane Diterpenes from the Gorgonian Briareum excavatum

Ping-Jyun Sung, Jui-Hsin Su, Guey-Horng Wang, Sung-Fang Lin, Chang-Yih Duh, and Jyh-Horng Sheu*
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, Republic of China
J. Nat. Prod., 1999, 62 (3), pp 457–463
DOI: 10.1021/np980446h
Publication Date (Web): February 9, 1999
Copyright © 1999 American Chemical Society and American Society of Pharmacognosy
*

 To whom correspondence should be addressed. Tel:  886-7-5252000 ext. 5030. Fax:  886-7-5255020.

Abstract

Eight new briarane-type diterpenes, excavatolides F−M (1−8), have been isolated from the gorgonian Briareum excavatum. The structures and relative stereochemistry of these compounds were established by spectral analysis and chemical methods. The cytotoxicity of these compounds toward various cancer cell lines has also been determined.

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History

  • Published In Issue March 26, 1999
  • Received October 7, 1998

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