Excavatolides U−Z, New Briarane Diterpenes from the Gorgonian Briareum excavatum

Jyh-Horng Sheu,*† Ping-Jyun Sung,† Jui-Hsin Su,† Guey-Horng Wang,† Chang-Yih Duh,† Ya-Ching Shen,† Michael Y. Chiang,‡ and I-Ting Chen‡
Department of Marine Resources and Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, Republic of China
J. Nat. Prod., 1999, 62 (10), pp 1415–1420
DOI: 10.1021/np990302i
Publication Date (Web): September 18, 1999
Copyright © 1999 American Chemical Society and American Society of Pharmacognosy
*

 To whom correspondence should be addressed. Tel.:  +886-7-5252000, ext. 5030. Fax:  +886-7-5255020. E-mail:  sheu@mail.nsysu.edu.tw.

,
†

 Department of Marine Resources.

,
‡

 Department of Chemistry.

Abstract

A recent study of the EtOAc extract of the gorgonian Briareum excavatum afforded six new diterpenes of the briarane skeleton, excavatolides U−Z (1−6). The structures and relative stereochemistry of metabolites 1−6 were assigned on the basis of NMR studies and chemical methods. The structure, including the relative configuration of excavatolide U (1), was further confirmed by a single-crystal X-ray analysis. Some of the excavatolides have displayed significant cytotoxicity toward P-388 and HT-29 tumor cells.

View: Full Text HTML | Hi-Res PDF

Tools

History

  • Published In Issue October 22, 1999
  • Received June 18, 1999

Recommend & Share

Related Content

Other ACS content by these authors: