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General Behavior, Toxicity, and Cytotoxic Activity of Elenoside, a Lignan from Justicia hyssopifolia

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Eduardo Navarro,*^† Simeona J. Alonso,^† Juan Trujillo,^‡ Elena Jorge,^‡ and Cirilo Pérez^‡

Department of Pharmacology, Faculty of Medicine, University of La Laguna, E-38071 La Laguna, Tenerife, Spain, and Centro de Productos Naturales y Agrobiologa, CSIC, Carretera de la Esperanza, 2, E-38206 La Laguna, Tenerife, Spain

J. Nat. Prod., 2001, 64 (1), pp 134–135

DOI: 10.1021/np9904861

Publication Date (Web): December 23, 2000

To whom correspondence should be addressed.

†

University of La Laguna.

‡

Centro de Productos Naturales y Agrobiología, CSIC.

Abstract

Cytotoxicity, acute toxicity, and general pharmacological effects in mice of an arylnaphthalene lignan isolated from Justicia hyssopifolia were studied. Elenoside was cytotoxic to human cancer cell lines in a range of concentrations from 10^-5 to 10^-4 M. It has an LD₅₀, ip in mice, of 305 mg/kg and central depressive properties at doses of 25, 50, and 100 mg/kg. Thus, elenoside appears to be a sedative with broad spectrum cytotoxicity.

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Published In Issue January 26, 2001
Received October 1, 1999

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General Behavior, Toxicity, and Cytotoxic Activity of Elenoside, a Lignan from Justicia hyssopifolia