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Letter

A Catalyst for Efficient and Highly Enantioselective Hydrogenation of Aromatic, Heteroaromatic, and α,β-Unsaturated Ketones

Supporting Info

Mark J. Burk,* William Hems, Daniela Herzberg, Christophe Malan, and Antonio Zanotti-Gerosa*

Chirotech Technology Limited, Ascot Fine Chemicals, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.

Org. Lett., 2000, 2 (26), pp 4173–4176

DOI: 10.1021/ol000309n

Publication Date (Web): December 1, 2000

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, azanotti-gerosa@ascotfine.com

Abstract

PhanePhos−ruthenium−diamine complexes catalyze the asymmetric hydrogenation of a wide range of aromatic, heteroaromatic, and α,β-unsaturated ketones with high activity and excellent enantioselectivity.

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Published In Issue December 28, 2000
Received October 10, 2000

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Letter

A Catalyst for Efficient and Highly Enantioselective Hydrogenation of Aromatic, Heteroaromatic, and α,β-Unsaturated Ketones