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Letter

Catalytic Synthesis of Aldehydes and Ketones under Mild Conditions Using TEMPO/Oxone

Carsten Bolm,* Angelika S. Magnus, and Jens P. Hildebrand

Institut fr Organische Chemie der RWTH Aachen, Professor-Pirlet-Strasse 1, D-52056 Aachen, Germany

Org. Lett., 2000, 2 (8), pp 1173–1175

DOI: 10.1021/ol005792g

Publication Date (Web): March 30, 2000

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, carsten.bolm@oc.rwth-aachen.de

Abstract

A novel, metal-free oxidation system for the catalytic synthesis of aldehydes and ketonesTEMPO/Oxonehas been developed. An optimized reaction protocol proved especially successful for the synthesis of ketones. Additionally, the influence of quarternary ammonium salts on the catalysis was studied. The mild conditions of this novel procedure were shown to tolerate even sensitive silyl protective groups which can otherwise be cleaved in the presence of Oxone.

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Published In Issue April 20, 2000
Received March 11, 2000

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Letter

Catalytic Synthesis of Aldehydes and Ketones under Mild Conditions Using TEMPO/Oxone

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

Iodine as a Chemoselective Reoxidant of TEMPO: Application to the Oxidation of Alcohols to Aldehydes and Ketones

A Very Mild and Chemoselective Oxidation of Alcohols to Carbonyl Compounds

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