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Letter

Synthesis of Tri- and Tetrasubstituted Furans Catalyzed by Trifluoroacetic Acid

Supporting Info

Frédéric Stauffer and Reinhard Neier*

Institute of Chemistry, University of Neuchtel, Avenue de Bellevaux 51, CH-2007 Neuchtel, Switzerland

Org. Lett., 2000, 2 (23), pp 3535–3537

DOI: 10.1021/ol0063205

Publication Date (Web): October 26, 2000

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, reinhard.neier@unine.ch

Abstract

Substituted 2-hydroxy-3-acetylfurans are synthesized by alkylation of tert-butyl acetoacetate with an α-haloketone followed by treatment of the obtained intermediate with trifluoroacetic acid (TFA). A second alkylation of the intermediate followed by treatment with trifluoroacetic acid provides access to disubstituted 2-methylfurans.

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