Enantiopure 2,3-Dihydro-4-pyridones as Synthetic Intermediates:  A Concise Asymmetric Synthesis of (+)-Allopumiliotoxin 267A

Daniel L. Comins,* Shenlin Huang, Cheryl L. McArdle, and Charles L. Ingalls
Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204
Org. Lett., 2001, 3 (3), pp 469–471
DOI: 10.1021/ol0069709
Publication Date (Web): January 10, 2001
Copyright © 2001 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, daniel_comins@ncsu.edu

Abstract

Abstract Image

A concise asymmetric synthesis of (+)-allopumiliotoxin 267A has been accomplished using an enantiopure dihydropyridone building block. The synthesis is highly stereoselective and requires 10 steps from readily available material.

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History

  • Published In Issue February 08, 2001
  • Received December 6, 2000

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