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Letter

A Simple Biomimetic Synthesis of Styelsamine B

Supporting Info

David Skyler and Clayton H. Heathcock*

Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, California 94720

Org. Lett., 2001, 3 (26), pp 4323–4324

DOI: 10.1021/ol010262l

Publication Date (Web): December 7, 2001

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, heathcock@cchem.berkeley.edu

Abstract

An extremely rapid, low cost, and environmentally friendly entry into the pyridoacridine family of alkaloids has been devised, as demonstrated here by the first total synthesis of styelsamine B (3) and its oxidation to the quinoneimine cystodytin J (4). The known reaction of cystodytin J with methanethiol makes this a formal synthesis of diplamine.

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Published In Issue December 27, 2001
Received November 7, 2001

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Letter

A Simple Biomimetic Synthesis of Styelsamine B

Abstract

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SciFinder Links

History

Recommend & Share

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