Direct Reductive Amination of Aldehydes and Ketones Using Phenylsilane:  Catalysis by Dibutyltin Dichloride

Richard Apodaca* and Wei Xiao
The R.W. Johnson Pharmaceutical Research Institute, San Diego, California 92121
Org. Lett., 2001, 3 (11), pp 1745–1748
DOI: 10.1021/ol015948s
Publication Date (Web): May 3, 2001
Copyright © 2001 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, rapodaca@prius.jnj.com

Abstract

Abstract Image

A procedure for direct reductive amination of aldehydes and ketones was developed which uses phenylsilane as a stoichiometric reductant and dibutyltin dichloride as a catalyst. Suitable amines included anilines and dialkylamines but not monoalkylamines.

Tools

History

  • Published In Issue May 31, 2001
  • Received April 5, 2001

Recommend & Share

Related Content

Other ACS content by these authors: