Letter
Synthesis of Aza Bicyclic Enones via Anionic Cyclization: Application to the Total Synthesis of (−)-Brunsvigine
In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.
Abstract

A general approach to the synthesis of aza bicyclic enones was developed via a simple two-step annulation involving a Mitsunobu protocol and anionic cyclization. According to this strategy the total synthesis of (−)-brunsvigine was accomplished with 12% overall yield.
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History
- Published In Issue July 12, 2001
- Received April 24, 2001
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