Direct Asymmetric Aldol Reactions of Acetone Using Bimetallic Zinc Catalysts

Barry M. Trost,* Elliad R. Silcoff, and Hisanaka Ito
Department of Chemistry, Stanford University, Stanford, California 94305-5080
Org. Lett., 2001, 3 (16), pp 2497–2500
DOI: 10.1021/ol0161211
Publication Date (Web): July 10, 2001
Copyright © 2001 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, bmtrost@stanford.edu

Abstract

Abstract Image

The enantioselective aldol reaction using a novel binuclear zinc catalyst of acetone with several aldehydes gave products in good yields (62−89%) with a high level of enantioselectivity (ee = 76−92%).

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History

  • Published In Issue August 09, 2001
  • Received May 14, 2001

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