2,2,2-Trifluoroethyl Formate:  A Versatile and Selective Reagent for the Formylation of Alcohols, Amines, and N-Hydroxylamines

David R. Hill,* Chi-Nung Hsiao, Ravi Kurukulasuriya, and Steven J. Wittenberger
Abbott Laboratories, Global Pharmaceutical R&D, 1401 Sheridan Road, D-R450, Bldg. R8, North Chicago, Illinois 60064-4000
Org. Lett., 2002, 4 (1), pp 111–113
DOI: 10.1021/ol016976d
Publication Date (Web): December 14, 2001
Copyright © 2002 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, david.hill@abbott.com

Abstract

Abstract Image

Treatment of a variety of alcohols, amines, and N-hydroxylamines with 2,2,2-trifluoroethyl formate gave the corresponding formylated adducts in high yields.

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History

  • Published In Issue January 10, 2002
  • Received October 30, 2001

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