An Efficient Route to Alkyl Chlorides from Alcohols Using the Complex TCT/DMF

Lidia De Luca, Giampaolo Giacomelli,* and Andrea Porcheddu
Dipartimento di Chimica, Universit degli Studi di Sassari, Via Vienna 2, I-07100 Sassari, Italy
Org. Lett., 2002, 4 (4), pp 553–555
DOI: 10.1021/ol017168p
Publication Date (Web): January 17, 2002
Copyright © 2002 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, ggp@ssmain. uniss.it

Abstract

Abstract Image

Efficient conversion of alcohols and β-amino alcohols to the corresponding chlorides (and bromides) can be carried out at room temperature in methylene chloride, using 2,4,6-trichloro[1,3,5]triazine and N,N-dimethyl formamide. This procedure can also be applied to optically active carbinols.

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History

  • Published In Issue February 21, 2002
  • Received December 4, 2001

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