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Letter

Effect of Ligand Structure on the Zinc-Catalyzed Henry Reaction. Asymmetric Syntheses of (−)-Denopamine and (−)-Arbutamine

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Barry M. Trost,* Vince S. C. Yeh, Hisanako Ito, and Nadine Bremeyer

Department of Chemistry, Stanford University, Stanford, California 94305-5080

Org. Lett., 2002, 4 (16), pp 2621–2623

DOI: 10.1021/ol020077n

Publication Date (Web): July 19, 2002

Abstract

Syntheses of variously modified ligands for the dinuclear zinc catalysts for the asymmetric aldol and nitroaldol (Henry) reactions are reported. Catalytic enantioselective nitroaldol reactions promoted by these modified ligands led to efficient syntheses of the β-receptor agonists (−)-denopamine and (−)-arbutamine.

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Published In Issue August 08, 2002
Received April 15, 2002

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Letter

Effect of Ligand Structure on the Zinc-Catalyzed Henry Reaction. Asymmetric Syntheses of (−)-Denopamine and (−)-Arbutamine

Abstract

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Related Content

A New Copper Acetate-Bis(oxazoline)-Catalyzed, Enantioselective Henry Reaction

A Direct Catalytic Enantioselective Aldol Reaction via a Novel Catalyst Design

Nanocrystalline MgO for Asymmetric Henry and Michael Reactions

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