Broadly Effective Enantioselective Diels−Alder Reactions of 1-Amino-substituted-1,3-butadienes

Yong Huang, Tetsuo Iwama, and Viresh H. Rawal*
Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637
Org. Lett., 2002, 4 (7), pp 1163–1166
DOI: 10.1021/ol0255716
Publication Date (Web): March 7, 2002
Copyright © 2002 American Chemical Society

Abstract

Abstract Image

A broad range of substituted 1-amino-1,3-butadienes undergo enantioselective Diels−Alder reactions with methacrolein in the presence of 5 mol % of Cr(III)-salen complex 1. The reactions are carried out conveniently, at room temperature, and they afford the cycloadducts in high yields and excellent ee's.

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History

  • Published In Issue April 04, 2002
  • Received January 16, 2002

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