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Letter

Ionic Liquid Acceleration of Solid-Phase Suzuki−Miyaura Cross-Coupling Reactions

Jefferson D. Revell and A. Ganesan*

Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, Southampton SO17 1BJ, United Kingdom

Org. Lett., 2002, 4 (18), pp 3071–3073

DOI: 10.1021/ol0263292

Publication Date (Web): August 9, 2002

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, ganesan@soton.ac.uk

Abstract

Room-temperature ionic liquids promote various transition metal-catalyzed reactions in the solution phase. Here, for the first time, we show that these effects are translatable to solid-phase reactions. The Suzuki−Miyaura cross-coupling of 4-iodophenol immobilized on polystyrene−Wang resin with various arylboronic acids was significantly accelerated by the ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF₄^-]).

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