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Letter

A General Method for the Formation of Aryl−Sulfur Bonds Using Copper(I) Catalysts

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Craig G. Bates, Rattan K. Gujadhur, and D. Venkataraman*

Department of Chemistry, University of Massachusetts, 710 N. Pleasant Street, Amherst, Massachusetts 01003

Org. Lett., 2002, 4 (16), pp 2803–2806

DOI: 10.1021/ol0264105

Publication Date (Web): July 12, 2002

To whom correspondence should be addressed.

, dv@chem.umass.edu

Abstract

We report a mild, palladium-free synthetic protocol for the cross-coupling reaction of aryl iodides and thiols using 10 mol % CuI and 10 mol % neocuproine, with NaOt-Bu as the base, in toluene at 110 °C. Using this protocol, we have shown that a variety of aryl sulfides can be synthesized in excellent yields from readily available iodides and thiols.

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Published In Issue August 08, 2002
Received June 21, 2002

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Letter

A General Method for the Formation of Aryl−Sulfur Bonds Using Copper(I) Catalysts

Abstract

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History

Recommend & Share

Related Content

A General, Efficient, and Inexpensive Catalyst System for the Coupling of Aryl Iodides and Thiols

A General and Long-Lived Catalyst for the Palladium-Catalyzed Coupling of Aryl Halides with Thiols A General and Long-Lived Catalyst for the Palladium-Catalyzed Coupling of Aryl Halides with Thiols

Aryl−Aryl Bond Formation One Century after the Discovery of the Ullmann Reaction

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