Catalytic Diastereoselective Pauson−Khand Reaction:  an Efficient Route to Enantiopure Cyclopenta[c]proline Derivatives

Biao Jiang* and Min Xu
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 354 Fenglin Road, Shanghai 200032, P. R. China
Org. Lett., 2002, 4 (23), pp 4077–4080
DOI: 10.1021/ol026826i
Publication Date (Web): October 19, 2002
Copyright © 2002 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, jiangb@pub.sioc.ac.cn

Abstract

Abstract Image

Cyclopenta[c]proline derivatives were synthesized in a stereocontrolled manner and in good yields via catalytic Pauson−Khand reactions. The starting materials, optically pure enyne amino acid derivatives, can be easily prepared by an alkenylboronic acid-mediated Mannich-type reaction.

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History

  • Published In Issue November 14, 2002
  • Received August 30, 2002

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