Prev. Article Next Article Table of Contents

Letter

Practical Synthesis of Aryl Triflates under Aqueous Conditions

Supporting Info

Doug E. Frantz,* Damian G. Weaver, James P. Carey, Michael H. Kress, and Ulf H. Dolling

Department of Process Research, Merck Research Laboratories, Merck & Co., 466 Devon Park Drive, Wayne, Pennsylvania 19087

Org. Lett., 2002, 4 (26), pp 4717–4718

DOI: 10.1021/ol027154z

Publication Date (Web): December 4, 2002

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, doug_frantz@merck.com

Abstract

A practical and efficient synthesis of aryl triflates under biphasic basic aqueous conditions is described. The current methodology provides entry into these valuable substrates that omits the use of amine bases and allows facile isolation by simple solvent evaporation after phase separation. Good yields can also be obtained without the use of organic solvent.

View: Full Text HTML | Hi-Res PDF

Tools

SciFinder Links

History

Published In Issue December 26, 2002
Received October 23, 2002
Revised November 19, 2002

Recommend & Share

Related Content

Palladium-catalyzed coupling of aryl triflates with organostannanesPalladium-catalyzed coupling of aryl triflates with organostannanesJournal of the American Chemical Society
- Palladium-catalyzed coupling of aryl triflates with organostannanesPalladium-catalyzed coupling of aryl triflates with organostannanes
  Antonio M. Echavarren, J. K. Stille
  Journal of the American Chemical Society 1987 109 (18), pp 5478–5486
  Abstract | Hi-Res PDF
Palladium-Catalyzed Decarboxylative Coupling of Allylic Alkynoates with ArynesOrganic Letters
- Palladium-Catalyzed Decarboxylative Coupling of Allylic Alkynoates with Arynes
  Shao-Feng Pi, Bo-Xiao Tang, Jin-Heng Li, Yi-Lin Liu and Yun Liang
  Organic Letters 2009 11 (11), pp 2309–2312
  Abstract: A novel and selective protocol for the synthesis of 1-allyl-2-ethynylbenzenes has been developed by palladium-catalyzed decarboxylative coupling of allylic alkynoates with arynes. This new route allows for both sp−sp² and sp²−sp³ couplings of allylic ...
  Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF
Fast Synthesis of Aryl Triflates with Controlled Microwave HeatingOrganic Letters
- Fast Synthesis of Aryl Triflates with Controlled Microwave Heating
  Anna Bengtson, Anders Hallberg, and Mats Larhed
  Organic Letters 2002 4 (7), pp 1231–1233
  Abstract: Synthesis of aryl triflates from phenols using N-phenyltriflimide requires only 6 min for completion when conducted with controlled microwave heating. The methodology was applied to both solution- and solid-phase conditions. Ten different aryl triflates ...
  Abstract | Full Text HTML | Hi-Res PDF

Letter

Practical Synthesis of Aryl Triflates under Aqueous Conditions

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Palladium-catalyzed coupling of aryl triflates with organostannanesPalladium-catalyzed coupling of aryl triflates with organostannanes

Palladium-Catalyzed Decarboxylative Coupling of Allylic Alkynoates with Arynes

Fast Synthesis of Aryl Triflates with Controlled Microwave Heating

Other ACS content by these authors:

JOURNALS

BOOKS

MAGAZINE

COMMUNITIES

DIRECTORIES & DATABASES