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Letter

Regioselective Reductive Coupling of Alkynes and Aldehydes Leading to Allylic Alcohols

Supporting Info

Kazuhiko Takai,* Shuji Sakamoto, and Takahiko Isshiki

Department of Applied Chemistry, Faculty of Engineering, Okayama University, Tsushima, Okayama 700-8530, Japan

Org. Lett., 2003, 5 (5), pp 653–655

DOI: 10.1021/ol0272996

Publication Date (Web): February 4, 2003

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, ktakai@cc.okayama-u.ac.jp

Abstract

Treatment of a mixture of a terminal alkyne and an aldehyde with CrCl₂ and a catalytic amount of NiCl₂ and triphenylphosphine in the presence of water in DMF at 25 °C gives a 1,2-disubstituted allylic alcohol regioselectively.

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Published In Issue March 06, 2003
Received November 18, 2002

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Letter

Regioselective Reductive Coupling of Alkynes and Aldehydes Leading to Allylic Alcohols

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

Highly Selective Catalytic Intermolecular Reductive Coupling of Alkynes and Aldehydes

Iridium-Catalyzed Addition of Acid Chlorides to Terminal Alkynes

Nickel-Catalyzed Cyclizations and Couplings with Vinylzirconium Reagents

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