Aldol- and Mannich-Type Reactions via in Situ Olefin Migration in Ionic Liquid

Xiao-Fan Yang,† Mingwen Wang,† Rajender S. Varma,‡ and Chao-Jun Li*†
Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, and Clean Processes Branch, National Risk Management Research Lab, U.S. Environmental Protection Agency, Cincinnati, Ohio 45268
Org. Lett., 2003, 5 (5), pp 657–660
DOI: 10.1021/ol0273102
Publication Date (Web): February 13, 2003
Copyright © 2003 American Chemical Society
†

 Tulane University.

,
‡

 U.S. Environmental Protection Agency.

,
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, cjli@tulane.edu

Abstract

Abstract Image

An aldol-type and a Mannich-type reaction via the cross-coupling of aldehydes and imines with allylic alcohols catalyzed by RuCl2(PPh3)3 was developed with ionic liquid as the solvent. The solvent/catalyst system could be reused for at least five times with no loss of reactivity.

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History

  • Published In Issue March 06, 2003
  • Received November 19, 2002

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