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Letter

Mild and Efficient Copper-Catalyzed Amination of Aryl Bromides with Primary Alkylamines

Supporting Info

Fuk Yee Kwong and Stephen L. Buchwald*

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Org. Lett., 2003, 5 (6), pp 793–796

DOI: 10.1021/ol0273396

Publication Date (Web): February 21, 2003

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, sbuchwal@mit.edu

Abstract

An efficient copper-catalyzed amination of aryl bromides with primary alkylamines was developed that uses commercially available diethylsalicylamide as the ligand. This amination reaction can be performed at 90 °C in good yield. A variety of functional groups are compatible with these reaction conditions. Preliminary results show that this reaction can be carried out under solvent-free conditions with comparable yields.

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Published In Issue March 20, 2003
Received November 22, 2002

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Letter

Mild and Efficient Copper-Catalyzed Amination of Aryl Bromides with Primary Alkylamines

Abstract

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History

Recommend & Share

Related Content

A General and Efficient Copper Catalyst for the Amidation of Aryl Halides

Highly Selective Room-Temperature Copper-Catalyzed C−N Coupling Reactions Highly Selective Room-Temperature Copper-Catalyzed C−N Coupling Reactions

The Copper-Catalyzed N-Arylation of Indoles

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