Primary 1-Arylcyclopropylamines from Aryl Cyanides with Diethylzinc and Titanium Alkoxides†

Stefan Wiedemann, Daniel Frank, Harald Winsel, and Armin de Meijere*
Institut fr Organische Chemie der Georg-August-Universitt Gttingen, Tammannstrasse 2, 37077 Gttingen, Germany
Org. Lett., 2003, 5 (5), pp 753–755
DOI: 10.1021/ol034021k
Publication Date (Web): February 4, 2003
Copyright © 2003 American Chemical Society
†

 Part 90 in the series “Cyclopropyl Building Blocks for Organic Synthesis.” For Part 89, see:  Liu, C.; Tamm, M.; Nötzel, M. W.; de Meijere, A.; Schilling, J. K.; Kingston, D. G. I. Tetrahedron Lett. 2003, in press. Part 88:  Tebben, G.-D.; Stratmann, C.; Rauch, K.; Williams, C. M.; de Meijere, A. Org. Lett. 2003, in press.

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*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, armin.demeijere@chemie.uni-goettingen.de

Abstract

Abstract Image

1-Aryl-substituted primary cyclopropylamines are conveniently prepared from aromatic nitriles and diethylzinc. The yields range from 40 to 56% for donor-substituted (five examples) to 62−82% for non- and acceptor-substituted substrates (nine examples).

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History

  • Published In Issue March 06, 2003
  • Received January 7, 2003

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