Prev. Article Next Article Table of Contents

Letter

An Air and Thermally Stable One- Component Catalyst for the Amination of Aryl Chlorides

Supporting Info

Danilo Zim and Stephen L. Buchwald*

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Org. Lett., 2003, 5 (14), pp 2413–2415

DOI: 10.1021/ol034561h

Publication Date (Web): June 13, 2003

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, sbuchwal@mit.edu

Abstract

In this paper we report a new, highly efficient palladacyclic precatalyst that is air, moisture, and thermally stable and obviates the need to employ a glovebox. We have developed a convenient one-component precatalyst for the amination of aryl chlorides that overcomes many of the limitations of those previously described.

View: Full Text HTML | Hi-Res PDF

Tools

SciFinder Links

History

Published In Issue July 10, 2003
Received March 31, 2003

Recommend & Share

Related Content

Simple, Efficient Catalyst System for the Palladium-Catalyzed Amination of Aryl Chlorides, Bromides, and TriflatesThe Journal of Organic Chemistry
- Simple, Efficient Catalyst System for the Palladium-Catalyzed Amination of Aryl Chlorides, Bromides, and Triflates
  John P. Wolfe, Hiroshi Tomori, Joseph P. Sadighi, Jingjun Yin, and Stephen L. Buchwald
  The Journal of Organic Chemistry 2000 65 (4), pp 1158–1174
  Abstract: Palladium complexes supported by (o-biphenyl)P(t-Bu)₂ (3) or (o-biphenyl)PCy₂ (4) are efficient catalysts for the catalytic amination of a wide variety of aryl halides and triflates. Use of ligand 3 allows for the room-temperature catalytic amination of ...
  Abstract | Full Text HTML | Hi-Res PDF
Expanding Pd-Catalyzed C−N Bond-Forming Processes: The First Amidation of Aryl Sulfonates, Aqueous Amination, and Complementarity with Cu-Catalyzed ReactionsJournal of the American Chemical Society
- Expanding Pd-Catalyzed C−N Bond-Forming Processes: The First Amidation of Aryl Sulfonates, Aqueous Amination, and Complementarity with Cu-Catalyzed Reactions
  Xiaohua Huang, Kevin W. Anderson, Danilo Zim, Lei Jiang, Artis Klapars, and Stephen L. Buchwald
  Journal of the American Chemical Society 2003 125 (22), pp 6653–6655
  Abstract: The first general method for the Pd-catalyzed amination of aryl tosylates and benzenesulfonates was developed utilizing ligand 1, which belongs to a new generation of biaryl monophosphine ligands. In addition, the new catalyst system for the first time ...
  Abstract | Full Text HTML | Hi-Res PDF
Highly Selective Room-Temperature Copper-Catalyzed C−N Coupling Reactions Highly Selective Room-Temperature Copper-Catalyzed C−N Coupling ReactionsJournal of the American Chemical Society
- Highly Selective Room-Temperature Copper-Catalyzed C−N Coupling Reactions Highly Selective Room-Temperature Copper-Catalyzed C−N Coupling Reactions
  Alexandr Shafir and Stephen L. Buchwald
  Journal of the American Chemical Society 2006 128 (27), pp 8742–8743
  Abstract: Through the use of cyclic β-diketones as supporting ligands, the copper-catalyzed coupling of aryl iodides with aliphatic amines occurs at room temperature in as little as 1 h. These high reaction rates allow for the coupling of a wide range of aryl and ...
  Abstract | Full Text HTML | Hi-Res PDF

Letter

An Air and Thermally Stable One- Component Catalyst for the Amination of Aryl Chlorides

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Simple, Efficient Catalyst System for the Palladium-Catalyzed Amination of Aryl Chlorides, Bromides, and Triflates

Expanding Pd-Catalyzed C−N Bond-Forming Processes: The First Amidation of Aryl Sulfonates, Aqueous Amination, and Complementarity with Cu-Catalyzed Reactions

Highly Selective Room-Temperature Copper-Catalyzed C−N Coupling Reactions Highly Selective Room-Temperature Copper-Catalyzed C−N Coupling Reactions

Other ACS content by these authors:

JOURNALS

BOOKS

MAGAZINE

COMMUNITIES

DIRECTORIES & DATABASES