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Letter

Highly Practical and Enantioselective Cu-Catalyzed Conjugate Addition of Alkylzinc Reagents to Cyclic Enones at Ambient Temperature

Supporting Info

Isaac J. Krauss and James L. Leighton*

Department of Chemistry, Columbia University, New York, New York 10027

Org. Lett., 2003, 5 (18), pp 3201–3203

DOI: 10.1021/ol034983r

Publication Date (Web): August 7, 2003

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, leighton@chem.columbia.edu

Abstract

A new ligand for Cu-catalyzed enantioselective additions of dialkylzincs to cyclic enones has been developed. In addition to providing good to excellent enantioselectivities with a range of cyclic enones and dialkylzincs, the ligand has several notworthy features: it can be readily prepared in just two steps, is an air-stable crystalline solid, and provides optimal performance at ambient temperature.

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Published In Issue September 04, 2003
Received June 2, 2003

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Letter

Highly Practical and Enantioselective Cu-Catalyzed Conjugate Addition of Alkylzinc Reagents to Cyclic Enones at Ambient Temperature

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Enantiospecific Total Syntheses of Kapakahines B and F

Double Bond Isomerization/Enantioselective Aza-Petasis−Ferrier Rearrangement Sequence as an Efficient Entry to Anti- and Enantioenriched β-Amino Aldehydes

Chemoselective Tryptophan Labeling with Rhodium Carbenoids at Mild pH

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