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Letter

Carbonylative Sonogashira Coupling of Terminal Alkynes with Aqueous Ammonia

Supporting Info

Mohamed S. Mohamed Ahmed and Atsunori Mori*

Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama 226-8503, Japan

Org. Lett., 2003, 5 (17), pp 3057–3060

DOI: 10.1021/ol035007a

Publication Date (Web): August 1, 2003

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, amori@res.titech.ac.jp

Abstract

Carbonylative coupling of phenylethyne with 4-methoxy-1-iodobenzene in the presence of 1 mol % PdCl₂(PPh₃)₂, 2 equiv of 0.5 M aqueous ammonia, and CO (1 atm) gives the corresponding α,β-alkynyl ketone in 72% isolated yield after stirring at room temperature for 41 h, while noncarbonylative coupling product is not obtained.

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Published In Issue August 21, 2003
Received June 5, 2003

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Letter

Carbonylative Sonogashira Coupling of Terminal Alkynes with Aqueous Ammonia

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

One-Pot Construction of Pyrazoles and Isoxazoles with Palladium-Catalyzed Four-Component Coupling

Pd-Catalyzed Copper-Free Carbonylative Sonogashira Reaction of Aryl Iodides with Alkynes for the Synthesis of Alkynyl Ketones and Flavones by Using Water as a Solvent

Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds

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