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Letter

R₃Al−R‘₃SiOTf: Novel and Powerful Reagent System for Stereospecific Alkylation−Silylation Reactions of Epoxides

Supporting Info

Ponnusamy Shanmugam and Masaaki Miyashita*

Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan

Org. Lett., 2003, 5 (18), pp 3265–3268

DOI: 10.1021/ol035075x

Publication Date (Web): August 9, 2003

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, miyasita@sci.hokudai.ac.jp

Abstract

A novel and powerful reagent system R₃Al−R‘₃SiOTf for the one-pot alkylation−silylation reaction of epoxides was discovered, and the reactions of various epoxides with the new reagent system have been demonstrated to occur stereospecifically giving rise to the corresponding alkylation−silylation products in excellent yields.

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