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Letter

Palladium-Catalyzed, Carboxylic Acid-Assisted Allylic Substitution of Carbon Nucleophiles with Allyl Alcohols as Allylating Agents in Water

Supporting Info

Kei Manabe and Shū Kobayashi*

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Org. Lett., 2003, 5 (18), pp 3241–3244

DOI: 10.1021/ol035126q

Publication Date (Web): August 13, 2003

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, skobayas@mol.f.u-tokyo.ac.jp

Abstract

Allylic substitution of allyl alcohols in water as a suspension medium has been realized using a combination of tetrakis(triphenylphosphine)palladium and a carboxylic acid such as 1-adamantanecarboxylic acid. Various substrates turned out to be applicable to this catalytic system.

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Published In Issue September 04, 2003
Received June 18, 2003

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Letter

Palladium-Catalyzed, Carboxylic Acid-Assisted Allylic Substitution of Carbon Nucleophiles with Allyl Alcohols as Allylating Agents in Water

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Water Enables Direct Use of Allyl Alcohol for Tsuji−Trost Reaction without Activators

Rh-Catalyzed Intramolecular Olefin Hydroacylation: Enantioselective Synthesis of Seven- and Eight-Membered Heterocycles

Amination of Allylic Alcohols in Water at Room Temperature

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